The MM Medic’s medical tubes is a universal solution for various medical fields.
The assortment allows to meet the requests of majority of specialists, who practice autoplasm application, PRP and platelets-enriched fibrin in various medical fields, including.
We supply 6 tubes types:
Tube
for plasma therapy with sodium citrate
Tube
for PRP with sodium citrate
Tube
for plasma therapy with sodium heparinate
Tube
for PRP with sodium citrate
Tube
for PRF-therapy
Tube
for APRF-therapy
Centrifuge
MM Medic
Thermostat
MM Medic
Butterfly-catheter
MM Medic 22G
Important
The tubes are produced at plant certified according to standard ISO 13485 (Medical Devices – Quality Management System). The tubes meet the requirement of Directive 93/42/EEC (medical devices).
The tubes meet the demands of Technical regulation related to medical devices (Cabinet of Ministers Resolution №753).
The tubes are made of high quality medical material.
Each tube is packed in individual hermetic package.
The sterility is ensured by gamma-ray sterilization.
The benefits of MM-Medic tubes
MM Medic is a national company which supplies high quality tubes at affordable price. The assortment of the production meets the requirements of the novices as well as the high qualified and experienced specialists who have the relevant skills in PRP and PRF practice.
PRP-therapy
Regardless of the number of platelets the plasma is characterized by significant treatment ability. It has been proven that intradermal injection of activated plasma stimulates the regeneration and improves the skin turgor.
The PRP-therapy is an injection of platelet rich plasma which was received from own patient’s blood. The injection has to be given into the injured organ.
The PRP is a plasma fraction of autologous blood. It contains a determined concentration of platelets, high level of growth factors, and other biologically active molecules.
PRP advantages
The PRP advantages in comparison with another revitalization methods
- Autologous biomaterial – no risk of allergic reaction
- Due to coreless structure there is no risk of mutation
- Complexity – a combination of biologically activated molecules, nutrients, plasma microelements with platelets growth factors the concentration allows to double the positive effect
- During the plasma fibrinogen activation the natural matrix-substrate of fibrin is built
The basic principles of
PRP-therapy
The key strength of PRP is high level of platelets. Platelets - blood corpuscle, providing inflammation regulation, regeneration, and clot formation in case the vascular walls are damaged. All these function are possible due to platelets containing three kind of granules with an unique mix from growth factors, hormones, and chemoattractant.
Platelet growth factors:
FGF – Fibroblast Growth Factor stimulates division and secretory activity of skin derma fibroblasts and mucous membranes. The production of hyaluronic acid, fibrillin, elastin and collagens enhances under the impact of this factor.
TGFβ – Transforming growth factor beta. A powerful fibrinogen which forces the secretory activity of fibroblastic cells. Under it's influence the fibroblasts secret the collagen of I, III, IV types, tissue inhibitor of metalloproteinase 1 stabilizing the connective tissue structure.
ILGF-1 – Insulin-like growth factor 1. It optimizes the metabolism, division and secretory activity of epithelial cells and connective tissue.
EGF – Epidermal Growth Factor, it stimulates the proliferation and keratinocyte differentiation.
PDGF – platelet-derived growth factor. It stimulates the production of myofibroblasts and new connective tissue.
VEGF - Vascular Endothelial Growth Factor. It stimulates the division of endothelial cells, the angiogenesis process and remodeling of derma microvasculature and mucous membranes.
In addition, the platelets granules contain vasoactive molecules (adrenalin, serotonin, purine) regulating vascular tone and microcirculation clarity.
The advantages of PRP
The growth factors and chemokines, which are secreted by platelets, provide:
- own stem cells induction and their homing
- adhesion regulation and cells migration
- unique cells type production – microfibroblasts which are suitable for reparation
- stimulate cells proliferation
- activate angiogenesis processes
- stimulate differentiation and secretory cells activation thus ensuring the production of de novo collagen, elastin, hyaluronic acid and proteoglycans.
Technology for obtaining PRР
The technology for obtaining PRP is simple and reliable. It includes 3 stages:
- blood draw (from 1 to 10 tubes)
- centrifugation
- extraction of platelets-enriched plasma and injection into the patient organism
PRP-therapy effects
In cosmetology
and dermatology
In Orthopedics
and traumatology
In surgery
In gynecology
In dentistry
In sports medicine
The PRF-therapy
The PRF-therapy belongs to regenerative medicine focused on tissue and human organs regeneration (reparation). It is an important feature of the therapy is a use of the own reserve of the organism.
PRF - Platelet Rich Fibrin – a bioproduct which is obtained from patient’s blood. It is a fibrin complex resulting from the plasma clotting activity and big amount of platelets with high concentration of growth factors.
A unique feature of the PRF-therapy compare to the PRP is its ability to release the growth factors. In addition, it has been proven that PRF contains much higher concentration of the growth factors compare to PRP. An application with platelets rich fibrin is widely used after various manipulations in order to stimulate the tissue regeneration. This activity is completely safe since own blood of the patient is used for PRF preparation. Due to platelets release, which are fixed in fibrin matrix, growth factors, the PRF-therapy provides an inner healing.
Growth Factors in PRF
FGF – Fibroblast Growth Factor stimulates division and secretory activity of skin derma fibroblasts and mucous membranes. The production of hyaluronic acid, fibrillin, elastin and collagens enhances under the impact of this factor.
TGFβ – Transforming growth factor beta. A powerful fibrinogen which empowers the secretory activity of fibroblastic cells. Under its influence the granulation tissue is created faster, the fibroblasts secret the collagen of I, III, IV types, tissue inhibitor of metalloproteinase 1 stabilizing the connective tissue structure. Additionally, this factor acts as anti-inflammatory cytokine thereby limiting the inflammation.
ILGF-1 – Insulin-like growth factor 1. It optimizes the metabolism, division and secretory activity of epithelial cells and connective tissue.
EGF – Epidermal Growth Factor, it stimulates the proliferation and keratinocyte differentiation.
PDGF – platelet-derived growth factor. It stimulates the production of myofibroblasts and new connective tissue.
VEGF – Vascular Endothelial Growth Factor. It stimulates the division of endothelial cells, the angiogenesis process and remodeling of derma microvasculature and mucous membranes. In addition, the platelets granules contain vasoactive molecules (adrenalin, serotonin, purine) regulating vascular tone and microcirculation clarity.
The benefits of PRF-treatment
Low level of inflammation risk: owing to the leukocytes and cytokines the PRF, which is applied to the wound surface or defect of mucous membrane and hard tissue, provides the creation of barrier protecting against the inflammation. Furthermore, the platelets and leukocytes belonging to PRF release the microbicidal factors which reduce the infection and inflammation.
The acceleration of healing: the PRF saturating the wounds and defective tissue stimulates the tissue regeneration due to growth factors, which stimulate own stem cells, cells proliferation and their secretory activity.
Safety and comfort: since the PRF is produced from patient’s blood it is absolutely biocompatible, there are no antigens and mutagens, less probability of microbe transmission.
Technology of PRF obtaining
The technology of PRF obtaining is simple and reliable.
It includes the following stages:
- blood draw (from 1 to 10 tubes)
- centrifugation
- clot extraction
- membrane and bung creation
- application of fibrin membranes
MM Medic’s tubes application
The key aspect of medical devices MM Medic offers is their universality and multi-functionality.
Using the MM Medic tubes you can do the healing and preventive procedure as an individual treatment or as a part of complex care.
Scientific research
Antonio Cortese, Giuseppe Pantaleo, Antonio Borri Platelet-rich fibrin (PRF) in implant dentistry in combination with new bone regenerative technique in elderly patients Int J Surg Case Rep. 2016; 28: 52–56. doi: 10.1016/j.ijscr.2016.09.022
Behnia-Willison F, Pour NR, Mohamadi B, Willison N. Use of Platelet-rich Plasma for Vulvovaginal Autoimmune Conditions Like Lichen Sclerosus. Plast Reconstr Surg Glob Open. 2016 Nov 23;4(11):e1124.
Cieślik-Bielecka A, Glik J, Skowroński R, Bielecki T. Benefit of Leukocyte- and Platelet-Rich Plasma in Operative Wound Closure in Oral and Maxillofacial Surgery. Biomed Res Int. 2016;2016:7649206
Dhillon MS, Patel S, John R. PRP in OA knee - update, current confusions and future options. SICOT J. 2017;3:27.
Dhurat R., Sukesh M.S. Principles and Methods of Preparation of Platelet-Rich Plasma: A Review and Author's Perspective J Cutan Aesthet Surg. 2014; 7(4): 189–197.
Eduardo Borie, Daniel García Oliví, Iara Augusta Orsi Platelet-rich fibrin application in dentistry: a literature review Int J Clin Exp Med. 2015; 8(5): 7922–7929.
Engebretsen L, Steffen K, Alsousou J, et al. IOC consensus paper on the use of platelet-rich plasma in sports medicine. British Journal of Sports Medicine. 2010;44(15):1072–1081
Fernandes G, Yang S. Application of platelet-rich plasma with stem cells in bone and periodontal tissue engineering. Bone Res. 2016;4:16036.
Joshi Jubert N, Rodríguez L, Reverté-Vinaixa MM, Navarro A. Platelet-Rich Plasma Injections for Advanced Knee Osteoarthritis: A Prospective, Randomized, Double-Blinded Clinical Trial. Orthop J Sports Med. 2017;5(2):2325967116689386
Kushida S1, Kakudo N, Morimoto N, Hara T, Ogawa T, Mitsui T, Kusumoto K. Platelet and growth factor concentrations in activated platelet-rich plasma: a comparison of seven commercial separation systems. J Artif Organs. 2014;17(2):186-92.
Martinez-Zapata MJ, Martí-Carvajal AJ. Autologous platelet-rich plasma for treating chronic wounds. Cochrane Database Syst Rev. 2016 May 25;(5):CD006899.
Platelet Rich Plasma (PRP) Guidelines, © International Cellular Medicine Society - 2011. Available from: http://www.cellmedicinesociety.org
Qi Li, Shuang Pan, Smit J. Dangaria Platelet-Rich Fibrin Promotes Periodontal Regeneration and Enhances Alveolar Bone Augmentation Biomed Res Int. 2013; 2013: 638043 doi: 10.1155/2013/638043
Stessuk T, Puzzi MB, Chaim EA, Alves PC Platelet-rich plasma (PRP) and adipose-derived mesenchymal stem cells: stimulatory effects on proliferation and migration of fibroblasts and keratinocytes in vitro. Arch Dermatol Res. 2016;308(7):511-20.
Zhong-Shan Wang, Zhi-Hong Feng, Guo-Feng Wu The use of platelet-rich fibrin combined with periodontal ligament and jaw bone mesenchymal stem cell sheets for periodontal tissue engineering Sci Rep. 2016; 6: 28126. doi: 10.1038/srep28126
